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These compounds work by mimicking natural hormones that regulate appetite and blood sugar

15 Modeling data suggest that loss of muscle mass varies by sex, representing 10-15% of total weight reduction in females and 20-25% of total weight reduction in males, in the absence of structured strength training

Similarly, in the United Kingdom Prospective Diabetes Study (UKPDS), only 34% of patients attained an A1c age 65) and patients with hepatic or renal disease are more likely to experience frequent and severe hypoglycemic reactions, particularly if the goals of therapy aim for inappropriately tight glycemic control (20)

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Tirzepatide is more extensively studied, has regulatory approval for specific indications, and may be preferred for studies requiring a more established evidence base