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Among these NAEs, exenatide accounted for 10,175 cases (35.14%), liraglutide for 3,686 cases (12.73%), lixisenatide for 256 cases (0.88%), dulaglutide for 6,034 cases (20.84%), semaglutide for 5,935 cases (20.50%), and tirzepatide for 2,867 cases (9.90%)

Concerning aging, she said, there may well be some differences in the bloodbrain barrier between young mice and very old mice, but she is not sure they could be detected with the methods she currently uses

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This speculation derived from the discovery by Stephen Bloom in London that injection of GLP-1 into the intracerebral ventricles strongly inhibited feeding in fasted rats