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Unlike some diabetic treatments, such as insulin, semaglutide demonstrates a reduced likelihood of low blood sugar (hypoglycemia)

Delayed gastric emptying: GLP-1 slows down the rate at which food leaves the stomach and enters the small intestine

It is expected to lead to expanded indications for semaglutide (potentially an indication for reduction of CV risk in obese patients)

Long-acting agents seem to have a lower incidence of gastrointestinal adverse effects (166), likely due to tachyphylaxis in gastric emptying with sustained GLP-1R stimulation

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