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Louis Bariatrics, this comes up often, especially from patients who are interested in medications like semaglutide or tirzepatide but feel hesitant about injections

Meta-analyses show berberine reduces body weight by approximately 2-3 kg (4.5-6.5 pounds) over 12-16 weeks, with improvements in fasting blood glucose, insulin sensitivity, and lipid profiles

[DOI] [PubMed] [Google Scholar] Diz-Chaves Y, Mastoor Z, Spuch C, Gonzlez-Matas LC, Mallo F

Regarding placement, the card in each pack with suggested areas is helpful, but don't be afraid to experiment to find what works best for your skin and comfort