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Expert Commentary The rise of GLP-1 receptor agonists like semaglutide and tirzepatide reflects a major shift in how we approach both type 2 diabetes and obesity

Chris Boshoff, Pfizer's chief scientific officer, said in the release

Endocrinologist John Wilding noted: "It was exciting, because all of a sudden we were in a league where we knew it would be much more impactful in terms of the effects on health." A year-long study (2018) of nearly 900 people with obesity found that between one-third and half taking semaglutide lost at least 15% of body weight, with at least three-quarters losing more than 5%

These target certain hormones in your gut, like glucagon-like peptide-1 (GLP-1)