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Quality assessment and critical appraisal for the systematic review of the included studies The methodological quality of the included studies was evaluated independently by two reviewers using the Study Quality Assessment Tools developed by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH), tailored to the design of each included study

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As it became apparent that the drugs also resulted in reduced appetite and weight loss, they were researched for this purpose and are now used to treat obesity as well

Maintaining adequate hydration becomes particularly important because dehydration can exacerbate common side effects, creating a problematic cycle