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However, intact BBB consisted of endothelial cells and tight junctions impedes the brain permeability of therapeutic agents, which largely comprises their therapeutic efficacy of CNS diseases

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The data, Phase 1b Heart-2 trial: - PCSK9 protein dropped 51 to 88% (dose-dependent) - LDL-C dropped up to 62% at the 1.0 mg/kg dose - Effects sustained 18 months - No serious adverse events - No dose-limiting toxicities Published today