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Description
In Phase 3 studies conducted under controlled conditions, tirz epatide demonstratedsubstantial and sustained reductions in body weight, with participants achieving average weight reductions of up to approximately 2223% over 72 weeks, depending on dose and study protocol

Despite this, recent safety concerns have emerged about a potential link to suicidal behavior [4]
10.1016/j.bjpt.2023.100574 [DOI] [PMC free article] [PubMed] [Google Scholar] 54

Various guidelines have been proposed to mitigate the risk of adverse events, which includes avoiding initiation in those at extremes of age, recent history of DKA and frequent history of severe fungal infection [30]

doi:10.1016/S0306-4522(96)00434-4 29
