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Gastrointestinal Pharmacology: Studying its effects on gastrointestinal transit, satiety signaling, and potential interactions with other peptide hormones

Compared to endogenous receptor ligands, retatrutide exhibits a stronger affinity for the GIP receptor than for the glucagon and GLP-1 receptors [112]

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While there appears to be some consistency in headache occurrence across the GLP-1 class, individual responses vary considerably