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Least-squares mean standard error changes from baseline to final heart rate were + 2.7 0.2, + 1.0 0.3, and + 3.0 0.4 bpm with exenatide QW, exenatide BID, and liraglutide, respectively, and 0.8 0.2 bpm with non-GLP-1RAs

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However, the effects of these drugs on adverse limb outcomes were poorly examined

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Clear role: high-efficacy anchor therapy with adherence advantages
