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Psychiatry 10, 313323

The STEP 1 trial reported an average body-weight reduction of 14.9% with branded injectable semaglutide 2.4 mg over 68 weeks

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The MHRA and EMA have reviewed the evidence and concluded there is no established causal link

For sarcopenia and age-related muscle dysfunction, GLP-1 RAs preserve muscle health through prevention of catabolic muscle protein breakdown, enhanced insulin and amino acid-stimulated muscle protein synthesis through improved mTOR pathway activation, reduced skeletal muscle inflammation and fibrosis, and enhanced mitochondrial biogenesis improving muscle metabolic efficiency [169,170,171,172]