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In these trials, Rybelsus showed superior weight loss compared to placebo and several active comparators including sitagliptin (a DPP-4 inhibitor), empagliflozin (an SGLT2 inhibitor), and liraglutide (an injectable GLP-1 receptor agonist)

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Side effects, safety, and the boxed warning All GLP-1 agonists (and tirzepatide, a GIP/GLP-1 dual agonist) share a well-characterized profile: nausea, vomiting, diarrhea, constipation, abdominal pain, and headache are common, especially during the first 48 weeks and after each dose escalation