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As further GIP-GLP-1 receptor co-agonists were developed those findings were confirmed [51]

Case report 2 was the only one in which we did not observe a reduction in the thickness of the subcutaneous tissue at the level of the upper abdomen, while in all cases, a reduction in thickness was observed in the lower abdomen, an area often involved in lipedema

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There can be significant side-effects, and experts have called for more research into a potential link between GLP-1 jabs and a rise in gallbladder removals by NHS England

However, most of the subjects included in the RCTs are PCOS patients with obesity/overweight, whereas a portion of PCOS women, which can even reach 50%, might present a lean phenotype