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A 2024 study published in Nature Scientific Reports surveying over 162,000 patients over an eight-year period reported a significant association of psychiatric symptoms in patients taking GLP-1 RAs, including a 195% risk of depression, 108% risk of anxiety, and 106% increased risk for suicidal behavior

Peak Levels During Dose Escalation Weeks PlexusDx patients beginning semaglutide typically start at a low dose and increase gradually over 4 to 8 weeks, allowing the body to adjust to side effects like nausea and digestive changes