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The efficacy and safety of weekly semaglutide (2.4 mg) for the treatment of overweight and obesity was investigated in the Semaglutide Treatment Effect in People with Obesity (STEP) programme, which included individuals with overweight (BMI 27 kg/m 2 ) and complications, including dyslipidaemia, hypertension, sleep apnoea, cardiovascular disease and type 2 diabetes, or individuals with obesity (BMI 30 kg/m 2 ) with or without complications [26, 34,35,36,37,38,39]

Short- and rapid-acting insulin can be added to basal insulin to intensify therapy to address prandial blood glucose levels

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Influence of BMI-associated genetic variants and metabolic risk factors on weight loss with semaglutide: a longitudinal clinico-genomic cohort study