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Currently, evidence regarding the impact of GLP-1 receptor agonists on major adverse liver outcomes (MALOs) in diabetic populations derives primarily from large retrospective cohort studies

A role in regulating DNA methylation of genes involved in neuroprotection and epigenetic modulators of neuronal growth (miRNA 34a), apoptosis (miRNA 212), and differentiation (miRNA 29c) was also observed

However, neither Trulicity nor Ozempic is approved for this use, unlike GLP-1 agonists such as Wegovy (semaglutide) and Mounjaro (tirzepatide), Administration: Both are administered once weekly by subcutaneous (under-the-skin) injection using an auto-injector pen

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While both tirzepatide and semaglutide were effective in reducing OSA incidence, no statistically significant difference was observed between the two medications