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And the researchers did not observe the liver toxicity that had plagued some earlier small molecule GLP-1 drugs

Early dumping is the result of rapid nutrient delivery into the small intestine

44 Interestingly, other macronutrients (for example fatty acids) do not induce proinsulin biosynthesis, in spite of their ability to act as potent secretagogues for insulin secretion

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Drugs such as metformin, traditionally used for managing diabetes, are also being prescribed for preventive purposes in those at high risk