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Description
- Dementia and Alzheimers disease

Shes living a fuller life than she has in years

Orforglipron shows what researchers call "biased signaling." It strongly activates the cAMP pathway while producing minimal activation of the beta-arrestin pathway

Therefore, precise control of the activation or repression of GLP-1 signaling in different body sites will be essential to develop an effective treatment with minimal off-target effects
Pierre-Louis: And I wanna talk a little bit more about what that means in terms of newer drugs coming out and successes and side effects
