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1 While the trial was not designed as a weight loss trial, participants in the trial who received semaglutide still lost an average of 9.4% of total body weight which was sustained throughout the trial

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Reduce fatty, greasy, and heavily spiced foods, which are harder to digest when gastric motility is already slowed

Notably, Orforglipron (EC 50 1.2 nM), a pyrazolopyridine derivative that acts as a biased partial agonist and is administered orally once daily, has entered Phase III clinical trial (NCT3502970)