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Finally, there is a marked inverse relationship between albuminuria and CKD regression/clinical outcomes, meaning that the higher the levels of albuminuria, the lower the chances of the kidney regaining some of its function, and vice versa, thus making albuminuria a suitable biomarker of CKD [39]

Grill, H

3 (2014): 10791092, 10.2337/db13-1455

Hence they stimulate the accumulation of lipid intermediate metabolites [lysophosphatidic acid (LPA), diacylglycerol (DAG), acylcarnitines and ceramides], which promote defects of the insulin signaling pathway, exacerbate IR and stimulate several signaling pathways related to inflammation and oxidative stress, creating a second vicious-cycle of a feed-forward effect [17, 2123]

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