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GLP-1 receptors are expressed in key reward-related brain regions , including: The ventral tegmental area (VTA) and nucleus accumbens , which form the core of the mesolimbic dopamine pathway The prefrontal cortex , involved in executive function and impulse control The amygdala , which processes emotional salience and stress responses The prevailing hypothesis suggests that GLP-1 receptor activation may modulate dopamine signalling in reward circuits

Patients should be referred to health coaches, dietitians, physiotherapists, or online weight management programmes for additional support

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Introduction Besides the traditional standard-of-care agents, newer classes of glucose-lowering agents have been introduced and changed the landscape of type 2 diabetes mellitus (T2DM) management (1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.van Bommel E.J.M., Muskiet M.H.A., van Baar M.J.B., Tonneijck L., Smits M.M., Emanuel A.L., Bozovic A., Danser A.H.J., Geurts F., Hoorn E.J., et al