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Patients who started tirzepatide but discontinued before reaching 10 mg lost 8.1% of baseline weight
On 7.2mg dose 33% loss that much, and only 17% lost that much on 2.4mg
In follow-up from the STEP 1 trial on semaglutide, average weight loss on semaglutide was 17.3% at week 68
If headaches persist beyond the first week, check whether you are eating enough calories, as appetite suppression from increasing GLP-1 can lead to inadvertent calorie restriction that causes headaches
The Best Supplements for GLP-1 Users in 2026 Best bundle overall GLP-1s suppress your appetite, resulting in reduced calorie intake
