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Mounjaro (tirzepatide) works by activating two hormones involved in appetite and blood sugar regulation: Retatrutide works on three hormones, which is why it is often referred to as a triple-agonist. It activates: The addition of glucagon is what makes retatrutide different

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Review findings The review confirms that incretin-based therapies have not only achieved their intended goal of T2D and obesity management but have also demonstrated clinically meaningful benefits across multiple organ systems

The trial enrolled 338 adults and tested doses from 1mg to 12mg weekly over 48 weeks