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Leptin treatment can relieve insulin resistance in the MKR mice, a specific mouse model of type 2 diabetes [247]

Rocca AS, and Brubaker PL

A further limitation of the analysis is the missing data that resulted from patients discontinuing the trial because of AEs and, in particular, because of fatal AEs

The number on the scale may be acting like the 'canary in the coal mine.' It may be telling us about swallowing issues, loss of smell, gastrointestinal dysfunction, frailty, muscle loss, medication interactions or changes in cognition long before these problems become obvious
