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doi: 10.1056/NEJMoa1504720 9 MarsoSPDanielsGHBrown-FrandsenKKristensenPMannJFENauckMAet al

Although pharmacological intervention on insulin resistance and weight loss in these patients may be extremely important, there are other demonstrated actions of this pharmacological class that are well beyond the treatment of the metabolic disorder

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Depot medroxyprogesterone acetate (DMPA) injection, whilst highly effective, has been more consistently associated with weight gain than other methods