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however, gastrointestinal adverse effects such as nausea, vomiting, and diarrhea are the most frequently reported, particularly during the initial treatment phase ( Additionally, weight loss with GLP-1 RAs is accompanied by reductions in lean mass, with skeletal muscle accounting for approximately 15%40% of total weight loss ( 6 Conclusion and future directions The data strongly supports that SLD, is fueled by common pathways of altered metabolism and chronic inflammation, which are the central precipitating factors for HCC development across MASLD, ALD, and to some extent, chronic viral etiologies

This is the first direct genetic evidence that variation in the drugs target gene contributes to why some people respond dramatically and others barely move

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