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Using a protocol of escalating doses, a once daily injection significantly decreased HbA1c by 1.1 to 1.6% in diabetic patients and also caused significant weight loss of 5% or greater in 54% of patients, leading to its approval in 2010 (21)

The care team and patient have access to resources, support and biomarker logging

A significant proportion (up to 70 %) discontinue GLP-1 treatment within one year

However, a significant reduction in left atrial volume [mean difference 8.7 mL ( 14.2, 3.2), P = 0.002] and in E/e ratio [mean difference 1.4 ( 2.7, 0.1), P = 0.03] [52] was reported