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Clinical Implications The STEP-HFpEF trial program, which includes STEP-HFpEF (in patients with HFpEF and obesity) and STEP-HFpEF DM (in patients with HFpEF, obesity, and T2DM) demonstrated significant benefits of weekly subcutaneous semaglutide 2.4 mg, improving physical function, alleviating symptoms, and promoting weight loss with potential disease-modifying effects.(12,13) The dual primary endpoints of change in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS ) and percentage weight loss at 52 weeks drove the positive results of the trials

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It reduces hunger via GLP-1 pathways in the brain, but it also directly activates fat-cell receptors that increase fat breakdown and energy expenditure

They will monitor your progress, assess your blood sugar levels, and regulate your treatment plan as needed

It is also important to note that CONTRAVE can cause a false-positive urine drug screen for amphetamines