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These medications are generally recommended for adults with a BMI of 30 or higher, or 27+ with weight-related health issues like type 2 diabetes or high blood pressure
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At the time the protocols were finalized, trial results for SURPASS-CVOT were not yet available
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This has led to speculation that GLP-2 may act indirectly on bone cells in humans, with the presence of GLP-2R on the parathyroid gland suggesting a potential link between GLP-2, PTH secretion, and bone turnover
