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Effect of adjunctive simvastatin on depressive symptoms among adults with treatment-resistant depression: a randomized clinical trial

They stimulate glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, slow gastric emptying, and promote satiety through central nervous system effects

Ren JJ, Zhang PD, Li ZH, Zhang XR, Zhong WF, Chen PL, et al
Multiple mechanisms may explain why we observed lower incidence of pancreatic cancer among patients receiving GLP-1 RAs

2025;82(9):e42630
