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Challenges: The key challenge for Sanofi is competition from more established and better marketed GLP-1 drugs, particularly those from Novo Nordisk and Eli Lilly

It is believed to work through multiple pathways, including: Blocking voltage-gated sodium channels , reducing neuronal excitability Enhancing GABA (gamma-aminobutyric acid) activity , an inhibitory neurotransmitter Antagonising glutamate receptors , further dampening excitatory neurotransmission Inhibiting carbonic anhydrase enzymes , though the clinical significance of this effect is uncertain While topiramate's primary indications are epilepsy and migraine prophylaxis, it has been observed to cause weight loss as a side effect, likely through appetite suppression and altered taste perception

It is important to note that retatrutide has not yet received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and it remains under clinical investigation

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Seino Y, Fukushima M, Yabe D, Seino Y, Fukushima M, Yabe D