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Individual results vary, and some patients may lose less or more than the averages reported in clinical research

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Critical limitations include: Heterogeneity : Different strains, doses, and formulations make comparisons difficult Small effect sizes : Weight changes are typically modest and may not be clinically significant Short duration : Most studies last 12 weeks or less, providing no data on sustained effects Publication bias : Negative studies may be underreported There is no high-quality evidence that probiotic supplements can replicate the substantial weight loss achieved with prescription medications like semaglutide or tirzepatide

Additionally, longer-term data will also be necessary to determine how durable maintenance effects remain over multiple years

The companys aggressive marketing of Ozempic for off-label weight loss use has come under particular scrutiny