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Diabetologia (2018) 61:246198

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But it does require precision

IMPORTANT SAFETY INFORMATION Common Side Effects may include nausea, vomiting, diarrhea, decreased appetite, constipation, stomach pain, heartburn, belching, gas, and injection site reactions

This is not true pharmacological tolerance in the classic sense, but rather the body finding a new equilibrium at the current level of receptor stimulation
