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0.96%, respectively) (Table 1)

Vital status was confirmed for 98.2% of subjects using SGLT2i at baseline and 98.6% of those not using it

Finally, RYGB leads to the normalization of brain m-opioid receptors, which are significantly reduced in various limbic and cortical regions in obesity [28]

Gastrointestinal side effects are the most commonly reported and include: Nausea (affecting 1040% of patients, depending on the specific GLP-1 agonist) Vomiting and diarrhoea (less common than nausea but can contribute to dehydration) Constipation (due to slowed gastric emptying) Abdominal discomfort or bloating These effects are typically most pronounced during treatment initiation and following dose increases

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