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In the mesolimbic system, GLP-1R activation has been shown to attenuate the rewarding effects of palatable food and addictive substances, indicating potential therapeutic applications for GLP-1R agonists in treating obesity and SUDs [19,20,21]

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Elaine Yu, who directs the Bone Density Center at Massachusetts General Hospital in Boston, didnt find this particular difference very clinically impactful, for the reason that the condition is often coded for incorrectly and is likely underdiagnosed in both groups

Their muscle-to-fat ratio usually still improves, but in particularly vulnerable populations, such as older adults, rapid and significant muscle loss can be a dangerous issue