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The focus remains on measurable metabolic outcomes, adherence sustainability, and long-term weight management rather than short-term comparisons

Gastrointestinal issues such as nausea, constipation, diarrhoea, and reduced appetite are the most reported symptoms with weight loss injections

For older adults, glycaemic targets should be individualised based on frailty, comorbidities, and hypoglycaemia risk, rather than applying fixed targets

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AMPK activation promotes fat oxidation and glucose uptake, supporting the metabolic claims