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Pros: Helps regulate appetite Lowers blood sugar Can result in significant weight loss Cons: Can lead to muscle loss if protein isnt prioritized Often regain weight after stopping Can cause digestive issues, nausea, or vomiting Long-term effects are still being studied Often expensive and not always covered by insurance Can Foods Naturally Promote GLP-1

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Traditional guidelines have emphasized metformin as initial treatment due to its proven safety, low cost, and cardiovascular benefits

They might not only be beneficial for GLP1R LoF carriers but also for obese and diabetics patients that are either resistant to current GLP1R agonists treatments or are suffering from serious adverse effects

lean mass +2.94%),15 with a clear superiority of SEMA 2.4 mg over LIRA 3 mg (15.8% vs 6.4%) as demonstrated in the STEP 8 study.16 The likelihood of reversal of diabetes by SEMA 2,4 mg was shown to be clearly superior to placebo in the STEP 10 study17 (Table 1)