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The hallmark of PD is the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), leading to diminished dopamine levels in the striatum

After 12 weeks, HFD-fed mice with fasting blood glucose levels (FBG) 11.1 mmol/L and impaired glucose tolerance were classified as diabetic

In a 10-week clinical trial, a daily dose of 20 mg oral semaglutide achieved a steady-state plasma concentration of 30 nM, and when daily dose of oral semaglutide was increased to 40 mg, the semaglutide plasma concentration reached about 60 nM (102), which was over a thousand times higher than the EC50 of semaglutide for GLP-1R activation (95)

In all cases, eligibility is confirmed through medical history review, blood work, metabolic assessment, and appropriate prescribing standards before treatment is initiated

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