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Large randomized clinical trials such as STEP 1 and SURMOUNT-1 have demonstrated mean total body weight reductions exceeding 10-20% with semaglutide and tirzepatide, respectively, positioning these medications as central components of contemporary obesity management [1,2]

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Zhang L., Yang M., Ren H., Hu H., Boden G., Li L., Yang G

10.1074/jbc.274.48.33851 13 ButeauJ.RoduitR.SusiniS.PrentkiM
