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What was studied: The incidence of major adverse cardiovascular events Outcome: Semaglutide reduced the relative risk of adverse cardiovascular events by 20%, translating to an absolute reduction of 1.5 percentage points, from 8.0% in placebo participants to 6.5% in semaglutide participants

By contrast, metformin appears to exert broader effects on pathways directly implicated in AD pathogenesis, including AMPK, insulin, and adipocytokine signaling

Dehydration from severe nausea, vomiting, or diarrhea can cause acute kidney injury, with or without existing kidney disease, 140 as well as heart palpitations, so efforts should be made to prevent dehydration

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