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Moreover, while the OUG defines an off-treatment period as at least 6 months, we defined it as 1 year, taking into account the rate of increase in BMI and other laboratory values after treatment discontinuation, as well as clinical expert opinion

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The risk of muscle loss is particularly pronounced in certain populations: older adults (age 65+) who already face age-related sarcopenia, sedentary individuals without resistance training stimulus for muscle preservation, and patients losing weight very rapidly