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The safety discussion should also go beyond common side effects. Tirzepatide has been associated with vomiting and diarrhoea that can lead to dehydration, and the product information advises caution in patients with severe gastrointestinal disease

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Semaglutide activates GLP-1 receptors in your brain to regulate appetite, but this same activation can trigger tension headaches or migraines in some patients during the first 24 weeks of treatment

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Tailored resistance exercise training can optimize changes in body composition by preserving lean mass while achieving fat loss when associated to hypocaloric diet or incretin therapy [38, 39]

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