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Inhibition of DPP-IV has been associated with immunomodulatory effects, resulting in enhanced T-cell function and immune responses

CoreValve/Medtronic then published their results for their self-expanding valve, enrolling over 1400 participants.(4) The rate of death in the TAVR group was non-inferior to the SAVR group, and a subsequent test for superiority actually showed TAVR was superior to surgery in these high risk patients

In a 12-week RCT (n=101), the same oral medication plus structured behavioral support led to: Greater weight loss (4.2% vs 2.7%) More clinical responders (60% vs 37%) Better habit and psychological outcomes No safety trade-offs Medication alone optimal outcomes