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ACE-I have side effects like all biologic agents

Extreme Rare Side Effects While semaglutide injections are generally well-tolerated, they can occasionally cause extreme rare side effects that warrant immediate medical attention

In cases where obesity presents a significant health risk and other weight management interventions have failed, tirzepatide may be considered an off-label option

This involves identifying underlying factors contributing to stone formation, such as metabolic disorders, dietary habits, or genetic predispositions