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Depression-driven behaviors like consuming high-calorie, low-nutrient foods and reduced physical activity [87] contribute to weight gain and increased visceral fats, which are critical in developing IR

Nonetheless, pharmacological therapeutic development for MAFLD based on the mechanisms of action, adverse events, and efficacy is reviewed and recommended in clinical practice guidelines (CPGs) issued by the liver international society in the Americas (AASLD), 6 Europe (EASL), 12 and Asia (APASL)

However, research in this area continues with several companies exploring novel GLP-1 treatment strategies

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