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Regarding genotype, the prevalence of CH in children with PWS was not significantly different among the paternal deletion, mUPD, and unclassified groups ( The relationship between thyroid function and recombinant human (rhGH) therapy, particularly the influence of rhGH on serum thyroid hormone levels and increased conversion of thyroxine (T4) to triiodothyronine (T3), has been evaluated in some studies ( The autoimmune cause of impaired thyroid function has never been described or studied in patients with PWS

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