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Furthermore, tirzepatide significantly lowered cardiac troponin T levels compared with placebo, indicating reduced myocardial injury, along with a concurrent decline in NT-proBNP levels

The energy expenditure increase may help explain the magnitude of weight loss and the observed preferential reduction in visceral and hepatic fat with dual agonist treatment

Plateaus happen even with perfect habits, due to changes in metabolism, hormones, and appetite regulation

AOD 9604 , a fragment of human growth hormone, targets fat metabolism through entirely different pathways than GLP-1 signaling

doi: 10.3389/fendo.2023.1202089 Received 07 April 2023 Accepted 06 June 2023 Published 27 June 2023 Volume 14 - 2023 Edited by Alexandre Benani, Centre National de la Recherche Scientifique (CNRS), France Reviewed by Kazuki Harada, University of Tokyo, Japan