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The honest mechanistic summary is that most of retatrutides plausible benefit for PCOS insulin resistance would likely be indirect mediated by dramatic weight and hepatic-fat loss with a smaller, harder-to-isolate contribution from direct hepatic and islet effects

However, this medication isn't recommended for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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References 1.Drucker DJ, et al