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van Oostveen WM, de Lange ECM

Lifestyle changes, such as improved nutrition, regular exercise, stress management, and sleep hygiene, are still essential

These help keep stools soft without causing cramping or urgency

Results Small intestinal adaptations to increased food intake with cold stress require GLP-1R and GLP-2R signaling To determine the impact of GLP-1R, GLP-2R, or GIPR on gut surface area expansion with cold stress, we used double receptor knockout mice for Glp1r / Gipr / (DIRKO) and Glp1r / Glp2r / (GLPDRKO) to account for overlapping or compensatory roles in the intestinotrophic action of these gut hormones 15,35,46