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The most well-known examples, apart from pioglitazone, are fenofibrate, pemafibrate, seladelpar, elafibranor and lanifibranor, which have been studied in various trials regarding their effect on liver inflammation and fibrosis, without particular success, with the exception of lanifibranor, a pan-PPAR agonist, which was shown in a phase 2b RCT (NATIVE-NCT03008070) to improve ballooning and inflammation, without worsening of fibrosis

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doi: 10.2337/dc22-1710 [DOI] [PMC free article] [PubMed] [Google Scholar] 58

The ISR was calculated from population-based C-peptide kinetic variables [21], using ISEC software (version 3.4a, September 1994), in which the insulin grid was set to equal the sample regimen, the basal measurement of C-peptide was included in the calculation and the error of C-peptide measurements was set to 5% [22]
Our biology, which once served us well in a feast-or-famine setting, now makes us vulnerable to an environment abundant in calorie-dense foods
